Persona 4 is just supposed to be a mess on PCSX2, and one of the reasons I bought a real PS2 was to play a modded copy of Persona 4 with English text but the Japanese voices, as it's one of my favorite RPGs ever made. I think I had to run that one 480p to eliminate those lines, but I forget exactly. Plus I had to do a lot of screwing around with the graphics settings or I'd get five or six vertical lines being rendered. When I played through Drakengard 1 I would get slowdown that would screw up the audio.
For instance, when I played God of War 1 on it treasure chests would randomly lose their textures after I had been playing say for half an hour, and then it would happen all the time. Click to expand.PCSX2 always feels awesome the first five minutes when I see everything rendered at much higher resolution, but when I have played full games on it I found the experience kind of lacking.